Scientific and Clinical Studies
Theralac® Probiotic Strains

Lactobacillus rhamnosus LR-44 (2 Billion CFU Per Capsule)
  1. Alander, M., J. Matto, W. Kneifel, M. Johansson, B. Kogler, R. Crittenden, T. Mattila-Sandholm, and M. Saarela. Effect of Galacto-Oligosaccharide Supplementation on Human Fecal Microflora and on Survival and persistence of Bifidobacterium lactis TB-12 in the gastrointestinal tract. Int. Dairy J. 2001; 11: 817-825.
  2. Matsumoto, M., T. Tadenuma, K. Nakamure, H. Kume, T. Imai, R. Kihara, M. Watanabe, and Y. Benno. 2000. Effect of Bifidobacterium lactis LKM 512 [TB-12] Yoghurt on Fecal Microflora in Middle to Old Aged Persons. Microbial Ecology in Health and Disease; 12: 77-80.
  3. Matsumoto, M., H. Ohishi, and Y. Benno. 2001. Impact of LKM5 Yoghurt [Bifidobacterium TB-12] on Improvement of Intestinal Environment of the Elderly. FEMS Immunology and Medical Microbiology; 31: 181-186.
  4. Hove, H., I. Nordgaard-Andersen, and P.B. Mortensen. 1994. Effect of Lactic Acid Bacteria on the Intestinal Production of lactate and Short-Chain Fatty Acids and the Absorption of Lactose. Am. J. Clin. Nutr; 59: 74-79.
  5. Saavedra, J.M., N.A. Bauman, I. Oung, J.A. Perman, and R.H. Yolken. 1994. Feeding of Bifidobacterium bifidum [TB-12] and Streptococcus thermophilus to Infants in Hospital for Prevention of Diarrhea and Shedding of Rotavirus. The Lancet; 344: 1046-1049.
  6. Link-Amster, H., F. Rochat, K.Y. Suadan, O. Mignot, and J.M. Aeschlimann. 1994. Modulation of a Specific Humoral Immune Response and Changes in Intestinal Flora Mediated Through Fermented Milk [Bifidobacterium TB-12] Intake. FEMS Immunology and Medical Microbiology; 10: 55-64.
  7. Langhendries, J.P., J. Detry, J. Van Hees, J.M. Lamboray, J.M. Darimont, M.J. Mozin, M.C. Secretin, and J. Senterre. 1995. Effect of a Fermented Infant Formula Containing Viable Bifidobacteria [TB-12] on the Fecal Flora Composition and pH of Healthy Full-Term Infants. J. of Pediatric Gastroenterology and Nutrition; 21: 177-181.
  8. Fukushima, Y., et al. Effect of Follow-Up Formula Containing Bifidobacteria [Bifidobacterium TB-12] on Fecal Flora and Fecal Metabolites in Healthy Children. Bioscience Microflora; 16(2): 65-72.
  9. Kiravainen, P., A. Ouwehand, E. Isolauri, and S. Salminen. 1998. The Ability of Probiotic Bacteria [Bifidobacterium TB-12] to Bind to Intestinal Mucus. FEMS Microbiology Letters; 167: 185-189.
  10. Fukushima, Y., Y. Kawata, H. Hara, A. Terada, and T. Mitsuoka. 1998. Effect of a Probiotic Formula [Containing Bifidobacterium TB-12] on Intestinal Immunoglobulin A Production in Healthy Children. Intl. J. of Food Microbiology; 42: 39-44.
  11. Saavedra, J., A. Abi-Hanna, N. Moore, and R. Yolken. 1998. Effect of Long Term Consumption of Infant Formulas with Bifidobacteria [Bifidobacterium TB-12] and S. thermophilus on Stool Patterns and Diaper Rash in Infants. J. Pediatr Gastroenterol Nutr; 27 (4): 483.
  12. Abi-Hanna, A., N. Moore, R. Yolken, and J. Saavedra. 1998. Long Term Consumption of Infant Formulas with Live Probiotic Bacteria [Bifidobacterium TB-12]: Safety and Tolerance. J. Pediatr Gastroenterol Nutr; 27(4): 484.
  13. Kankaanpaa, P., Y. Sutas, S. Salminen, and E. Isolauri. 1998. Results on Clinical Demonstration of Probiotics [Containing Bifidobacterium TB-12] on Children. Presented at Functional Food Research in Europe, Third Workshop, PROBDEMO, Finland, Oct. 1-2, 1998.
  14. Haschke, F., W. Wang, G. Ping, W. Varavithya, A. Podhipak, F. Rochat, H. Link-Amster, A. Pfeifer, E. Diallo-Ginstl, and P. Steenhout. 1998. Clinical Trials Prove the Safety and Efficacy of the Probiotic Strain Bifidobacterium TB-12 in Follow-Up Formula and Growing- Up Milks. Monatsschr Kinderheilkd (Suppl. 1); 146: S26-S30.
  15. Fukushima, Y., Y. Kawata, K. Mizumachi, J. Kurisaki, and T. Mitsuoka. 1999. Effect of Bifidobacteria [TB-12] Feeding on Fecal Flora and Production of Immunoglobulins in Lactating Mouse. Intl. J. of Food Microbiol; 46: 193-197.
  16. Miettinen, M., et al. 1998. The Survival of and Cytokine Induction by Lactic Acid Bacteria [Bifidobacterium TB-12] After Passage Through a Gastrointestinal Model. Microbial Ecology in Health and Disease; 10: 141-147.
  17. Vanderhoof, J., and R. Young. 1998. Invited Review: Use of Probiotics in Childhood Gastrointestinal Disorders. J. of Pediatric Gastroenterology and Nutrition; 27: 323-332.
  18. Silva, A.M., E.A. Bambirra, A.L. Oliveira, P.P. Souza, D.A. Gomes, E.C. Vieira, and J.R. Nicoli. 1999. Protective Effect of Bifidus Milk [Containing Bifidobacterium TB-12] on the Experimental Infection with Salmonella enteritidis subsp. typhimurium in Conventional and Gnotobiotic Mice. J. of Applied Microbiology; 86: 331-336.
  19. Wagner, R.D., C. Pierson, T. Warner, M. Dohnalek, J. Farmer, L. Roberts, M. Hilty, and E. Balish. 1997. Biotherapeutic Effects of Probiotic Bacteria [Bifidobacterium TB-12] on Candidiasis in Immunodeficient Mice. Infection and Immunity; 65(10): 4165-4172.
  20. Wagner, R.D., et al. 1998. Biotherapeutic Effects of Bifidobacterium spp. [TB-12] on Orogastric and Systemic Candidasis in Immunodeficient Mice. Rev. Iberoam. Micology; 15: 265-270.
  21. Isolauri, E., T. Arvola, Y. Sutas, E. Moilanen, and S. Salminen. 2000. Probiotics [Bifidobacterium TB-12] in the Management of Atopic Eczema. Clinical and Experimental Allergy; 30: 1604-1610.
  22. Schiffrin, E.J., D. Brassart, A.L. Servin, F. Rochat, and A. Donnet-Hughes. 1997. Immune Modulation of Blood Leucocytes in Humans by Lactic Acid Bacteria [Bifidobacterium TB-12]: Criteria and Strain Selection. Am. J. Clin. Nutr; 66: 515S-520S.
  23. Kirjavainen, P.V., T. Arvola, S.J. Salminen, and E. Isolauri. 2002. Aberrant Composition of Gut Microbiota of Allergic Infants: A target of Bifidobacterial Therapy at Weaning [Bifidobacterium TB-12]? Gut; 51; 51-55.
  24. Matsumoto, M., H. Tani, H. Ono, and Y. Benno. 2002. Adhesive Property of Bifidobacterium lactis LKM512 [TB-12] and Predominant Bacteria of the Intestinal Microflora to Human Intestinal Mucin. Current Microbiology; 44: 212-215.
  25. Kankaanpaa, P.E. et al. 2002. Influence of Probiotic [Bifidobacterium TB-12] Supplemented Infant Formula on Composition of Plasma lipids in Atopic Infants. J. of Nutritional Biochemistry; 13: 364-369.
  26. Ouwehand, A.C., S. Salminen, S. Tolkko, P. Roberts, J. Ovaska, and E. Salminen. 2002. Resected Human Colonic Tissue: New Model for Characterizing Adhesion of Lactic Acid Bacteria. Clinical and Diagnostic Laboratory Immunology; 9: 184-186.
  27. Satokari, R.M., et al. 2001. Bifidobacterial Diversity in Human Feces Detected by Genus- Specific PCR and Denaturing Gradient Gel Electrophoresis. Appl. and Environmental Microbiology; 67(2): 504-513.
  28. Lim, K.S., C.S. Huh, and Y.J. Baek. 1993. Antimicrobial Susceptibility of Bifidobacteria. 1993. J. of Dairy Science; 76: 2168-2174.

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