Scientific and Clinical Studies
Theralac® Probiotic Strains

Lactobacillus acidophilus strain LA-1 (5 Billion CFU Per Capsule)
  1. Black, F.T., et al. 1991. Effect of lactic Acid Producing Bacteria [Lactobacillus acidophilus LA-1] on Human Intestinal Microflora During Ampicillin Treatment. Scand. J. Infect. Dis; 23: 247-254.
  2. Ellegaard, J., N.A. Peterslund, and F.T. Black. 1992. Infection Prophlaxis in Neutropenic Patients by Oral Administration of lactobacilli {L. acidophilus LA-1]. Presented at The Seventh International Symposium on Infections in the Immunocompromised Host, June 21- 24, 1992, Boulder. CO.
  3. Alm, L., E. Ryd-Kjellen, G. Setterberg, and L. Blomquist. 1993. Effect of a New Fermented Milk Product [Containing Bifidobacterium TB-12 and L. acidophilus LA-1] “CULTURA” on Constipation in Geriatric Patients. 1st Lactic Acid bacteria Computer Conference Proceedings. Horizon Scientific Press, Norfolk, England.
  4. Black, F.T, P.L. Anderson, J. Orskov, F. Orskov, K. Gaarslev, and S. Laulund. 1989. Prophylactic Efficacy of Lactobacilli [L. acidophilus LA-1] on Traveler’s Diarrhea. Travel Medicine; pp333-335.
  5. Kim, H-Y, H-S. Bae, and Y-J. Baek. 1991. In vivo Antitumor Effects of Lactic Acid Bacteria [L. acidophilus LA-1] on Sarcoma 180 and Mouse Lewis Lung Carcinoma. J. of Korean Cancer; 23: 188-195.
  6. Hatcher, G., R. Lambrecht. 1993. Augmentation of Macrophage Phagocytic Activity by Cell-Free Extracts of Selected Lactic Acid Producing Bacteria [L. acidophilus LA-1]. J. of Dairy Science; 76: 2485-2492.
  7. Nord, C.E., A. Lidbeck, K. Orrhange, and S. Sjostedt. 1997. Oral Supplementation with Lactic Acid Bacteria [L. acidophilus LA-1] During Intake of Clindamycin. Clinical Microbiology and Infection; 3(1): 124-132.
  8. Klaver, F., and R. van der Meer. 1993. The Assumed Assimilation of Cholesterol by Lactobacilli [L. acidophilus LA-1] and Bifidobacterium bifidum [TB-12] is due to their Bile Salt Deconjugating Activity. Appl. and Environ. Microbiol; 59(4): 1120-1124.
  9. Driessen, F.M., and R. de Boer. 1989. Fermented Milks with Selected Intestinal Bacteria: A Healthy Trend in New Products. Netherlands Milk Dairy Journal; 43: 367-382.
  10. Schiffrin, E.J. F. Rochat, H. Link-Amster, J.M. Aeschlimann, and A. Donnet-Hughes. 1995. Immunomodulation of Human Blood Cells [by Ingesting the Lactic Acid Bacteria L.acidophilus LA-1 and B. bifidum TB-12]. Nestle Research Center, Switzerland.
  11. Mierrinen, M., J. Vuopio-Varkila, and K. Varkila. 1996. Production of Human Tumor Necrosis Factor Alpha, Interleukin-6 and Interleukin-10 is Induced by Lactic Acid Bacteria [L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12]. Infection and Immunity; 64(12): 5403-5405.
  12. Biffi, A., D. Coradini, R. Larsen, L. Riva, and G. DiFronzo. 1997. Antiproliferative Effect of Fermented Milk [Containing L. acidophilus LA-1] on the Growth of a Human Breast Cancer Cell Line. Nutrition and Cancer; 28(1): 93-99.
  13. Salminen, S. et al. Development of Selection Criteria for Probiotic Strains to Assess their Potential in Functional Foods [Lactobacillus acidophilus LA-5 (LA-1) and Bifidobacterium TB-12]. A Nordic and European Approach. 1996. Bioscience Microflora; 15(2): 61-67.
  14. Obradovic, D., M. Curic, M. Ivanovic, B. Trbojevic, and M. Djordevic. 1996. Probiotic Function of the Fermented Milk Jogurt Plus [Containing L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12]. FEMS Conference (Fifth Symposium on Lactic Acid Bacteria), Holland, Sept. 8-12.
  15. Virta, P., K. Otterstrom, L. Niemi, M-T. Wieser-Aho, A-L. Lahteenmaki, and T. Leppanen. 1993. The Effect of a Preparation Containing Freeze-Dried Lactic Acid Bacteria [L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12] on Lactose Intolerance. External Report, Pharmacia, Finland.
  16. Black, F.T., P.L. Andersen, and S. Laulund. 1995. Report from a Double Blind Placebo Controlled Trial with HIP Against Traveler’s Diarrhea with a New Dosage Regimen. [L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12 are used] Internal report, Marselisborg Hospital, Denmark.
  17. Sanders, M.E., D. Walker, K. Walker, K. Aoyama, and T. Klaenhammer. 1996. Performance of Commercial Cultures [L. acidophilus LA-1 and Bifidobacterium TB-12] in Fluid Milk Applications. J. of Dairy Science; 79: 943-955.
  18. Lewis, S.J. and A.R. Freedman. 1998. Review Article: The Use of Biotherapeutic Agents in the Prevention and Treatment of Gastrointestinal Disease. Aliment Pharmacol. Therapy; 12: 807-822.
  19. Salminen, S., et al. 1998. Demonstration of Safety of Probiotics – A Review. Intl. J. of Food Microbiology; 44: 93-106.
  20. Ouwehand, A.C., P.V. Kirjavainen, C. Shortt, and S. Salminen. 1999. Probiotics: Mechanisms and Established Effects. [L. acidophilus LA-1 and Bifidobacterium TB-12 referenced]. Intl. Dairy Journal; 9: 43-52.
  21. Ouwehand, A.C., S. Tolkko, J. Kulmala, S. Salminen, and E. Salminen. 2000. Adhesion of Inactivated Probiotic Strains [L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12] to Intestinal Mucus. Letters in Appl. Microbiology; 31: 82-86.
  22. Tejada-Simon, M.V., J.H. Lee, Z. Ustunol, and J.J. Pestka. 1999. Ingestion of Yogurt Containing Lactobacillus acidophilus [LA-5 (LA-1)] and Bifidobacterium [TB-12] to Potentiate Immunoglobulin A Responses to Cholera Toxin in Mice. J. of Dairy Science; 82: 649-660.
  23. Juntunen, M., P.V. Kirjavainen, A.C. Ouwehand, S.J. Salminen, and E. Isolauri. 2001. Adherence of Probiotic Bacteria [L. acidophilus LA-5 (LA-1) and Bifidobacterium TB-12] to Human Intestinal Mucus in Healthy Infants and During Rotavirus Infection. Clinical and Diagnostic Laboratory Immunology, Vol. 8.

Note: Some references refer to this strain as LA-5. Bifidobacterium TB-12 is also included in some of the references cited for LA-1.

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